Effects: We clearly show for the first time that the differentiation of hmoDCs while in the existence of WIN55,212-2 generates tolerogenic Get-hmoDCs which can be fewer attentive to LPS stimulation and ready to prime Tregs. WIN55,212-2 also impairs the pro-inflammatory polarization of human macrophages by inhibiting cytokine creation, inflammasome activation https://win55.clinic/the-thao