TAK-243 preferentially sure to UBA1 more than the related E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased levels of ubiquitylated proteins, amplified markers of proteotoxic strain and DNA injury tension. In vivo, TAK-243 diminished leukemic stress and targeted leukemic stem cells with https://johnathanyrvqh.blogs100.com/29410190/5-essential-elements-for-ponicidin