Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals with the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific tests have identified recurrent mutations in genes regulating tumor mobile-microenvironment intera... https://jenningsq898pgw7.wikibestproducts.com/user